Description

Bz-Tz-Nhs CAS NO 1244040-64-9 is a specialized heterocyclic compound featuring a benzotriazole (Bz) core linked to an N-hydroxysuccinimide (NHS) ester moiety. This bifunctional structure is engineered to serve as a highly effective coupling agent and reactive intermediate in advanced synthetic chemistry. It is primarily utilized by research institutions and industrial R&D departments focused on pharmaceuticals, agrochemicals, and material science. The compound's design facilitates efficient conjugation and labeling processes critical for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for targeted drug delivery systems.
• Bioconjugation Reagent: Used for labeling proteins, peptides, and antibodies with fluorescent dyes, drugs, or other functional molecules via its NHS ester group.
• Polymer Modification: Functionalization of polymers and surfaces to introduce specific chemical handles for further reactions or to alter material properties.
• Proteomics Research: Employed in chemical proteomics for activity-based protein profiling (ABPP) and cross-linking studies.
• Agrochemical Synthesis: Intermediate in the development of novel herbicides, fungicides, and plant growth regulators.
• Diagnostic Reagent Development: Conjugation of haptens or detection molecules in immunoassay and biosensor development.
• Linker Chemistry: Serves as a cleavable or stable linker in solid-phase synthesis and combinatorial chemistry libraries.
• Material Science: Surface engineering of nanoparticles and quantum dots for biomedical imaging and sensing applications.

Basic Information

Product Name	Bz-Tz-Nhs
CAS No.	1244040-64-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1H-Benzotriazol-1-yl N-hydroxysuccinimide ester; Benzotriazole NHS Ester; Bz-Tz-NHS Ester; 1-(1H-Benzotriazol-1-yl)-2,5-pyrrolidinedione; NHS-activated benzotriazole; BzTz-NHS; BTZ-NHS; Coupling agent 1244040-64-9
EINECS	Contact for details

Quality Control

Our Bz-Tz-Nhs is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We adhere to cGMP principles where applicable to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.