Description

Benzyl 5-(Trifluoromethyl)Spiro[Indoline-3,4'-Piperidine]-1'-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a complex spirocyclic indoline-piperidine scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel drug candidates targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers seeking to build sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential active pharmaceutical ingredients (APIs) for neurological and psychiatric conditions.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its privileged spirocyclic structure.
• Protease Inhibitor Development: The spiro[indoline-3,4'-piperidine] core is a common motif in the development of inhibitors for various enzymes.
• Library Synthesis for High-Throughput Screening (HTS): Serves as a versatile scaffold for generating diverse compound libraries for biological screening.
• Preclinical Drug Development: Employed in the synthesis of compounds for pharmacokinetic, pharmacodynamic, and toxicology studies.

Basic Information

Product Name	Benzyl 5-(Trifluoromethyl)Spiro[Indoline-3,4'-Piperidine]-1'-Carboxylate
CAS No.	1243328-71-3
Molecular Formula	C21H19F3N2O2
Molecular Weight	388.38 g/mol
Synonyms	Benzyl 5-(trifluoromethyl)spiro[indole-3,4'-piperidine]-1'-carboxylate; 1'-[(Benzyloxy)carbonyl]-5-(trifluoromethyl)spiro[indoline-3,4'-piperidine]; 5-(Trifluoromethyl)-1'H-spiro[indoline-3,4'-piperidine]-1'-carboxylic acid benzyl ester; Spiro[Indoline-3,4'-Piperidine]-1'-carboxylic Acid, 5-(Trifluoromethyl)-, Benzyl Ester; 1243328-71-3; Benzyl 5-(Trifluoromethyl)Spiro[Indoline-3,4'-Piperidine]-1'-Carboxylate
EINECS	Contact for details

Quality Control

Our production of Benzyl 5-(Trifluoromethyl)Spiro[Indoline-3,4'-Piperidine]-1'-Carboxylate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and MS for identity verification. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with the rigorous standards required for pharmaceutical R&D. Our processes are designed to support development under cGMP guidelines when required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.