Description

(3S,5R)-Rosuvastatin CAS NO 1242184-42-4 is a key stereoisomeric intermediate in the synthesis of Rosuvastatin Calcium, a leading HMG-CoA reductase inhibitor (statin) used to manage hyperlipidemia. This high-purity intermediate is critical for ensuring the final active pharmaceutical ingredient (API) meets stringent pharmacopeial standards for efficacy and safety. It is primarily required by pharmaceutical manufacturers and advanced research organizations engaged in the development and production of cardiovascular therapeutics.

Application

• Pharmaceutical Intermediate: Primary use as a critical chiral building block in the synthesis of Rosuvastatin Calcium API.
• Active Pharmaceutical Ingredient (API) Development: Serves as a key starting material (KSM) or advanced intermediate in the multi-step synthesis of the final statin drug substance.
• Process Chemistry & Research: Used in route scouting, process optimization, and scale-up studies for more efficient Rosuvastatin manufacturing.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Regulatory Filings: Supplied for use in the preparation of Drug Master Files (DMFs) and regulatory submission packages.

Basic Information

Product Name	(3S,5R)-Rosuvastatin
CAS No.	1242184-42-4
Molecular Formula	C₂₂H₂₈FN₃O₆S
Molecular Weight	481.54 g/mol
Synonyms	(3S,5R)-Rosuvastatin; (3S,5R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic Acid; (3S,5R)-Rosuvastatin Free Acid; Rosuvastatin (3S,5R)-Isomer; (3S,5R)-Crestor Intermediate; ZD4522 (3S,5R)-Isomer
EINECS	Contact for details

Quality Control

Our (3S,5R)-Rosuvastatin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay and impurity profiling by HPLC, to ensure it meets the high standards required for pharmaceutical synthesis. Certificates of Analysis (COA) detailing identity, purity, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Chiral HPLC)	≥ 99.0% (3S,5R)-Isomer
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.