Description

5-Bromo-2-Ethoxy-3-(2,2,2-Trifluoroethoxy)Pyridine is a high-value, multi-functional pyridine derivative designed for advanced chemical synthesis. This compound is a critical pharmaceutical intermediate, prized for its unique halogenated and fluorinated alkoxy substitution pattern which enables the construction of complex bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers and liquid crystals.
• Chemical Research: A versatile reagent for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution due to the reactive bromine substituent.
• Fluorine Chemistry: Valuable scaffold for introducing the trifluoroethoxy group into target molecules, a moiety known to improve metabolic stability and lipophilicity.

Basic Information

Product Name	5-Bromo-2-Ethoxy-3-(2,2,2-Trifluoroethoxy)Pyridine
CAS No.	1241752-46-4
Molecular Formula	C9H9BrF3NO2
Molecular Weight	300.07 g/mol
Synonyms	5-Bromo-2-ethoxy-3-(2,2,2-trifluoroethoxy)pyridine; 3-(2,2,2-Trifluoroethoxy)-5-bromo-2-ethoxypyridine; 2-Ethoxy-5-bromo-3-(2,2,2-trifluoroethoxy)pyridine; 5-Bromo-2-ethoxy-3-(trifluoroethoxy)pyridine; Pyridine, 5-bromo-2-ethoxy-3-(2,2,2-trifluoroethoxy)-; CAS 1241752-46-4
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Ethoxy-3-(2,2,2-Trifluoroethoxy)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.