Description

5-Bromo-3-(2,2-difluoroethoxy)-2-methoxypyridine is a high-value, multi-functional pyridine derivative designed for advanced chemical synthesis. This compound serves as a critical building block in modern pharmaceutical and agrochemical research, offering unique reactivity due to its bromine and difluoroethoxy substituents. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for creating novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the difluoroethoxy group can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a sophisticated scaffold for constructing novel ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the creation of specialty polymers and advanced organic electronic materials due to its electron-deficient pyridine core.
• Custom Synthesis and Contract Manufacturing: An essential starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	5-Bromo-3-(2,2-difluoroethoxy)-2-methoxypyridine
CAS No.	1241752-42-0
Molecular Formula	C8H8BrF2NO2
Molecular Weight	268.06 g/mol
Synonyms	5-Bromo-3-(2,2-difluoroethoxy)-2-methoxypyridine; 2-Methoxy-5-bromo-3-(2,2-difluoroethoxy)pyridine; 3-(2,2-Difluoroethoxy)-5-bromo-2-methoxypyridine; 1241752-42-0; Pyridine, 5-bromo-3-(2,2-difluoroethoxy)-2-methoxy-
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-(2,2-difluoroethoxy)-2-methoxypyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.