Description

3-Bromo-4-(2-Hydroxypropan-2-Yl)Picolinonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated picolinonitrile structure. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce specific bromine and nitrile functionalities into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in kinase inhibitor programs.
• Agrochemical Synthesis: Used as a precursor in the creation of novel herbicides and pesticides with tailored activity.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in catalytic processes.
• Material Science Research: Employed in the development of organic electronic materials and functional polymers.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of client-specific target molecules under cGMP conditions.

Basic Information

Product Name	3-Bromo-4-(2-Hydroxypropan-2-Yl)Picolinonitrile
CAS No.	1240595-87-2
Molecular Formula	C9H9BrN2O
Molecular Weight	241.09 g/mol
Synonyms	3-Bromo-4-(2-hydroxy-2-propyl)picolinonitrile; 4-(2-Hydroxypropan-2-yl)-3-bromopicolinonitrile; 2-Bromo-6-cyano-3-(2-hydroxypropan-2-yl)pyridine; 3-Bromo-4-(1-hydroxy-1-methylethyl)picolinonitrile; 3-Bromo-4-(2-hydroxy-2-propyl)-2-pyridinecarbonitrile; 1240595-87-2; 2-Pyridinecarbonitrile, 3-bromo-4-(1-hydroxy-1-methylethyl)-
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-(2-Hydroxypropan-2-Yl)Picolinonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with client specifications. Our quality commitment supports applications from research to commercial-scale cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.