Description

tert-Butyl 3,5-Difluoro-4-(Hydroxymethyl)Benzoate is a high-value, multi-functional aromatic building block featuring a protected carboxylic acid group and a hydroxymethyl moiety. This compound is critical for the synthesis of complex molecules where precise fluorine substitution and orthogonal protecting group strategies are required. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and anti-cancer agent research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides where the difluoro and hydroxymethyl groups confer specific biological activity.
• Liquid Crystal Materials: Serves as a precursor for fluorine-containing mesogens used in display technologies.
• Polymer Chemistry: Monomer or co-monomer for creating specialty polymers with enhanced thermal and chemical resistance.
• Organic Synthesis Reagent: Employed in cross-coupling reactions and as a scaffold for constructing complex polycyclic aromatic structures in academic and industrial R&D.
• Fluorinated Probe Development: Useful in medicinal chemistry for creating 18F or 19F-labeled compounds for imaging and diagnostic applications.

Basic Information

Product Name	tert-Butyl 3,5-Difluoro-4-(Hydroxymethyl)Benzoate
CAS No.	1239964-17-0
Molecular Formula	C12H14F2O3
Molecular Weight	244.24 g/mol
Synonyms	4-(Hydroxymethyl)-3,5-difluorobenzoic acid tert-butyl ester; tert-Butyl 4-(hydroxymethyl)-3,5-difluorobenzoate; 3,5-Difluoro-4-(hydroxymethyl)benzoic acid tert-butyl ester; Benzoic acid, 3,5-difluoro-4-(hydroxymethyl)-, 1,1-dimethylethyl ester; tert-Butyl 3,5-difluoro-4-(hydroxymethyl)benzoate; CAS 1239964-17-0
EINECS	Contact for details

Quality Control

Our tert-Butyl 3,5-Difluoro-4-(Hydroxymethyl)Benzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.