Description

tert-Butyl 1-Benzyloxycarbonylamino-6-Azaspiro[2.5]Octane-6-Carboxylate is a sophisticated, high-purity organic building block featuring a unique spirocyclic and protected amine-carboxylate architecture. This compound matters as a critical intermediate in the synthesis of novel pharmaceutical candidates, particularly those targeting complex biological pathways. It is primarily needed by research and development teams in the pharmaceutical and biotechnology sectors for constructing advanced molecular scaffolds in drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and metabolic disorder targets.
• Protease Inhibitor Research: Used in the development of protease inhibitors due to its structural similarity to transition-state analogs.
• Peptidomimetic Chemistry: Serves as a constrained, non-natural amino acid analog for creating stable peptide mimetics with enhanced bioavailability.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and protein-protein interactions.
• Library Synthesis for High-Throughput Screening: Utilized in combinatorial chemistry to generate diverse compound libraries for biological screening.
• Advanced Material Science: Potential precursor for specialty polymers or ligands in catalyst systems, leveraging its rigid spiro structure.

Basic Information

Product Name	tert-Butyl 1-Benzyloxycarbonylamino-6-Azaspiro[2.5]Octane-6-Carboxylate
CAS No.	1239852-32-4
Molecular Formula	C20H28N2O4
Molecular Weight	360.45 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-6-[(1,1-dimethylethoxy)carbonyl]-6-azaspiro[2.5]octane; 6-[(tert-Butoxy)carbonyl]-1-[(benzyloxy)carbonyl]-6-azaspiro[2.5]octane; tert-Butyl 1-(Cbz-amino)-6-azaspiro[2.5]octane-6-carboxylate; 1-N-Cbz-6-N-Boc-6-azaspiro[2.5]octane; Boc-6-Azaspiro[2.5]octane-1-Cbz; 6-Azaspiro[2.5]octane-1,6-dicarboxylic acid, 1-(phenylmethyl) ester, 6-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-Benzyloxycarbonylamino-6-Azaspiro[2.5]Octane-6-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure compliance with research-grade standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.