Description

2-((4-Methylphenyl)Sulfonyl)-2-Azaspiro[3.3]Heptane-6-Carboxylic Acid CAS NO 1237542-12-9 is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and sulfonamide scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel small-molecule therapeutics targeting a range of diseases. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potential drug candidates, especially those requiring a constrained spirocyclic architecture.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to develop molecules with improved potency, selectivity, and pharmacokinetic properties.
• Protease Inhibitor Development: The sulfonamide and carboxylic acid functionalities make it a relevant precursor for designing inhibitors of various enzymes, including proteases.
• Chemical Biology Probes: Can be utilized to create tool compounds for investigating biological pathways and target validation.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) campaigns.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, non-commercial APIs under cGMP conditions.

Basic Information

Product Name	2-((4-Methylphenyl)Sulfonyl)-2-Azaspiro[3.3]Heptane-6-Carboxylic Acid
CAS No.	1237542-12-9
Molecular Formula	C15H19NO4S
Molecular Weight	309.38 g/mol
Synonyms	2-(p-Tolylsulfonyl)-2-azaspiro[3.3]heptane-6-carboxylic acid; 2-((4-Methylphenyl)sulfonyl)-2-azaspiro[3.3]heptane-6-carboxylic acid; 2-Azaspiro[3.3]heptane-6-carboxylic acid, 2-[(4-methylphenyl)sulfonyl]-; 2-Tosyl-2-azaspiro[3.3]heptane-6-carboxylic acid; 1237542-12-9; 2-(4-Methylbenzenesulfonyl)-2-azaspiro[3.3]heptane-6-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2-((4-Methylphenyl)Sulfonyl)-2-Azaspiro[3.3]Heptane-6-Carboxylic Acid is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our quality commitment supports compliance with ISO standards and meets the stringent requirements for pharmaceutical R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is light-sensitive (store away from light). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.