Description

2-Azaspiro[3.3]Heptane-6,6-Dicarboxylic Acid, 2-[(4-Methylphenyl)Sulfonyl]-, 6,6-Bis(1-Methylethyl) Ester is a sophisticated spirocyclic building block and a key intermediate in modern organic synthesis. This compound is valued for its rigid, three-dimensional scaffold and functional handles, which are critical for constructing complex molecular architectures with precise spatial control. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and optimization of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where its spirocyclic structure can contribute to improved biological activity and environmental stability.
• Chemical Biology Probe Synthesis: Serves as a scaffold for creating molecular probes to study enzyme function and protein-protein interactions within biological systems.
• Material Science Precursor: Potential use in the synthesis of specialty polymers and advanced organic materials requiring specific conformational rigidity.
• Asymmetric Catalysis Ligand Synthesis: The structure can be elaborated to create novel chiral ligands for asymmetric synthesis, enabling the production of enantiomerically pure compounds.

Basic Information

Product Name	2-Azaspiro[3.3]Heptane-6,6-Dicarboxylic Acid, 2-[(4-Methylphenyl)Sulfonyl]-, 6,6-Bis(1-Methylethyl) Ester
CAS No.	1237542-10-7
Molecular Formula	C22H31NO6S
Molecular Weight	437.55 g/mol
Synonyms	2-(p-Toluenesulfonyl)-2-azaspiro[3.3]heptane-6,6-dicarboxylic acid diisopropyl ester; Diisopropyl 2-(4-methylphenyl)sulfonyl-2-azaspiro[3.3]heptane-6,6-dicarboxylate; 2-Tosyl-2-azaspiro[3.3]heptane-6,6-dicarboxylic acid diisopropyl ester; 2-Azaspiro[3.3]heptane-6,6-dicarboxylic acid, 2-[(4-methylphenyl)sulfonyl]-, bis(1-methylethyl) ester; 2-(4-Methylbenzenesulfonyl)-2-azaspiro[3.3]heptane-6,6-dicarboxylic acid diisopropyl ester; 2-(p-Tolylsulfonyl)-2-azaspiro[3.3]heptane-6,6-dicarboxylic acid diisopropyl ester; 2-Ts-2-azaspiro[3.3]heptane-6,6-dicarboxylate diisopropyl ester
EINECS	Contact for details

Quality Control

Our 2-Azaspiro[3.3]Heptane-6,6-Dicarboxylic Acid, 2-[(4-Methylphenyl)Sulfonyl]-, 6,6-Bis(1-Methylethyl) Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.