Description

1-(4-Bromo-Phenyl)-Cyclobutanecarboxylic Acid Methyl Ester is a high-purity, versatile chemical building block, specifically an ester derivative of a brominated phenylcyclobutane carboxylic acid. This compound is valued for its unique cyclobutane ring structure and bromine substituent, which make it a critical intermediate in advanced organic synthesis. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, including potential active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel therapeutic compounds, particularly those targeting central nervous system (CNS) disorders or inflammatory pathways.
• Agrochemical Synthesis: Serves as a precursor in the creation of advanced herbicides, fungicides, or insecticides, leveraging the bromine atom for further functionalization.
• Ligand and Catalyst Development: Used in organometallic chemistry to develop specialized ligands or catalysts for asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, or advanced polymers where the rigid cyclobutane core imparts specific material properties.
• Academic & Contract Research: Essential for methodological studies and exploratory chemistry in university and CRO (Contract Research Organization) laboratories.

Basic Information

Product Name	1-(4-Bromo-Phenyl)-Cyclobutanecarboxylic Acid Methyl Ester
CAS No.	1236357-65-5
Molecular Formula	C12H13BrO2
Molecular Weight	269.14 g/mol
Synonyms	Methyl 1-(4-bromophenyl)cyclobutanecarboxylate; 1-(p-Bromophenyl)cyclobutanecarboxylic Acid Methyl Ester; 4-Bromo-α,α-cyclobutanebenzenepropanoic Acid Methyl Ester; Cyclobutanecarboxylic acid, 1-(4-bromophenyl)-, methyl ester; Methyl 1-(4-bromophenyl)cyclobutan-1-carboxylate
EINECS	Contact for details

Quality Control

Every batch of 1-(4-Bromo-Phenyl)-Cyclobutanecarboxylic Acid Methyl Ester is produced and tested under a strict quality management system. We guarantee high chemical purity and consistency, supported by comprehensive analytical characterization including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles to meet the stringent requirements of research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.