Description

(4R,5R)-2-Chloro-3,4-Dimethyl-2,5-Diphenyl-1-Oxa-3-Aza-2-Silacyclopentane CAS NO 1236123-69-5 is a high-purity, stereochemically defined organosilicon heterocycle, serving as a critical chiral building block and protecting group reagent in advanced organic synthesis. Its value lies in enabling precise stereocontrol and functional group manipulation, which are essential for developing complex molecules with high biological activity. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Chiral Auxiliary in Asymmetric Synthesis: Used to induce stereoselectivity in the formation of new carbon-carbon and carbon-heteroatom bonds.
• Intermediate for Pharmaceutical APIs: Serves as a key precursor in the multi-step synthesis of potential drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Intermediate: Employed in the research and development of novel, stereospecific pesticides and herbicides.
• Silicon-Based Protecting Group: The silacyclopentane structure can act as a protecting group for alcohols or amines during complex synthetic sequences.
• Ligand Precursor for Catalysis: Can be modified to create novel chiral ligands for transition metal-catalyzed reactions.
• Material Science Research: Investigated as a monomer or additive for creating specialized silicon-containing polymers with unique properties.

Basic Information

Item	Details
Product Name	(4R,5R)-2-Chloro-3,4-Dimethyl-2,5-Diphenyl-1-Oxa-3-Aza-2-Silacyclopentane
CAS No.	1236123-69-5
Molecular Formula	C18H20ClNOSi
Molecular Weight	329.90 g/mol
Synonyms	(4R,5R)-2-Chloro-3,4-dimethyl-2,5-diphenyl-1-oxa-3-aza-2-silacyclopentane; 2-Chloro-3,4-dimethyl-2,5-diphenyl-1-oxa-3-aza-2-silacyclopentane, (4R,5R)-; Chiral Silacyclopentane Derivative; Organosilicon Heterocycle; Siloxazolidine Derivative
EINECS	Contact for details

Quality Control

Our (4R,5R)-2-Chloro-3,4-Dimethyl-2,5-Diphenyl-1-Oxa-3-Aza-2-Silacyclopentane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high chemical and stereochemical purity, meeting the stringent requirements for research and process chemistry. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.