Description

Propanoic Acid, 3-[2-(Phenylmethoxy)Ethoxy]-, 1,1-Dimethylethyl Ester is a specialized organic ester compound, also known as a tert-butyl protected derivative of a PEGylated phenyl ether carboxylic acid. This chemical is a high-value building block and intermediate designed for advanced synthesis, offering a unique combination of a protected carboxylic acid group and a benzyl-protected polyethylene glycol (PEG) spacer. It is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries who require precise molecular architecture for drug discovery, prodrug development, and the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring PEGylation or specific carboxylic acid protection strategies.
• Prodrug Synthesis: Used to create prodrug candidates where the tert-butyl ester acts as a cleavable protecting group, modulating solubility and bioavailability.
• Bioconjugation & Linker Chemistry: Serves as a precursor for constructing heterobifunctional crosslinkers and spacers used in antibody-drug conjugates (ADCs) and other bioconjugation applications.
• Polymer & Material Science: A monomer or functionalization agent for creating specialty polymers with tailored hydrophilicity, biodegradability, or surface properties.
• Organic Synthesis & Medicinal Chemistry: Provides a versatile handle for introducing functionalized ethoxy chains into complex molecular scaffolds during research and development.
• Ligand & Catalyst Development: Used in the preparation of specialized ligands for catalysis or as a component in metal-organic frameworks (MOFs).

Basic Information

Item	Details
Product Name	Propanoic Acid, 3-[2-(Phenylmethoxy)Ethoxy]-, 1,1-Dimethylethyl Ester
CAS No.	1235715-30-6
Molecular Formula	C16H24O4
Molecular Weight	280.36 g/mol
Synonyms	tert-Butyl 3-[2-(benzyloxy)ethoxy]propanoate; 3-[2-(Benzyloxy)ethoxy]propanoic acid tert-butyl ester; 1,1-Dimethylethyl 3-[2-(phenylmethoxy)ethoxy]propanoate; tert-Butyl 3-(2-(benzyloxy)ethoxy)propanoate; PEG2 benzyl ether tert-butyl ester; BnO-PEG2-propionic acid t-butyl ester; BnO-(CH2CH2O)2-CH2CH2COO-tBu
EINECS	Contact for details

Quality Control

Our Propanoic Acid, 3-[2-(Phenylmethoxy)Ethoxy]-, 1,1-Dimethylethyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting critical parameters such as assay, impurity profile, and residual solvents. Our quality commitment supports applications requiring GMP-grade starting materials and research-grade purity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC/GC)	≥ 97.0%
Purity (HPLC Area %)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.