Description

Siponimod is a potent and selective sphingosine-1-phosphate (S1P) receptor modulator, specifically targeting the S1P1 and S1P5 subtypes. This targeted mechanism of action makes it a critical active pharmaceutical ingredient (API) for the development of advanced immunomodulatory therapies. It is primarily utilized by pharmaceutical companies and research institutions engaged in the development and manufacturing of treatments for autoimmune and neurological disorders, such as multiple sclerosis.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the key therapeutic component in finished dosage forms for the treatment of relapsing forms of multiple sclerosis (MS).
• Clinical Research Material: Serves as a reference standard and investigational compound in preclinical and clinical studies exploring new therapeutic applications.
• Drug Development Intermediate: Used in the synthesis and process development of next-generation S1P receptor modulators.
• Biochemical Research: A vital tool for studying S1P receptor biology, lymphocyte trafficking, and autoimmune disease mechanisms in laboratory settings.

Basic Information

Product Name	Siponimod
CAS No.	1234627-85-0
Molecular Formula	C29H35FN2O3
Molecular Weight	478.60 g/mol
Synonyms	BAF312; Mayzent; 1-{4-[(1E)-1-({[4-cyclohexyl-3-(trifluoromethyl)phenyl]amino}carbonyl)ethenyl]-2-ethylbenzyl}azetidine-3-carboxylic acid; (E)-1-(4-(1-((4-Cyclohexyl-3-(trifluoromethyl)phenyl)carbamoyl)vinyl)-2-ethylbenzyl)azetidine-3-carboxylic acid; Siponimod free base
EINECS	Contact for details

Quality Control

Our Siponimod is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.10%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.