Description

tert-Butyl 5-Bromo-3-(Chloromethyl)Pyrrolo[2,3-B]Pyridin-1-Carboxylate is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters because it provides a versatile scaffold for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs). Pharmaceutical researchers and fine chemical manufacturers need this key intermediate for its reactive bromo and chloromethyl handles, which enable precise derivatization and coupling reactions in drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of kinase inhibitors and other small-molecule therapeutics targeting oncology and central nervous system (CNS) disorders.
• Agrochemical Research: Used as a building block for developing novel pesticides and herbicides with specific biological activity.
• Material Science: Serves as a monomer or functional unit in the creation of specialty polymers and organic electronic materials.
• Chemical Biology: Employed in the design and synthesis of molecular probes and tool compounds for biological target validation.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Nucleophilic Substitution: The reactive chloromethyl group allows for further functionalization through alkylation or amination reactions.

Basic Information

Product Name	tert-Butyl 5-Bromo-3-(Chloromethyl)Pyrrolo[2,3-B]Pyridin-1-Carboxylate
CAS No.	1234616-42-2
Molecular Formula	C13H14BrClN2O2
Molecular Weight	345.62 g/mol
Synonyms	1-Boc-5-Bromo-3-(chloromethyl)-7-azaindole; 5-Bromo-3-(chloromethyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester; tert-Butyl 5-bromo-3-(chloromethyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate; 5-Bromo-3-chloromethyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester; 1H-Pyrrolo[2,3-b]pyridine-1-carboxylic acid, 5-bromo-3-(chloromethyl)-, 1,1-dimethylethyl ester; 5-Bromo-3-(chloromethyl)-1-((2-methylpropan-2-yl)oxy)carbonyl-1H-pyrrolo[2,3-b]pyridine; Boc-5-Bromo-3-chloromethyl-7-azaindole
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Bromo-3-(Chloromethyl)Pyrrolo[2,3-B]Pyridin-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.