Description

Cyclobutanecarboxylic Acid, 3,3-Difluoro-, Methyl Ester is a high-purity fluorinated building block of significant interest in advanced organic synthesis. This compound is valued for its unique structural motif, which incorporates both a strained cyclobutane ring and fluorine atoms, enabling precise modulation of molecular properties. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides where the fluorinated cyclobutane structure can enhance bioactivity and environmental stability.
• Advanced Material Precursor: Serves as a monomer or specialty additive in the development of performance polymers, liquid crystals, and organic electronic materials.
• Fluorine Chemistry Research: An essential reagent for studying structure-activity relationships (SAR) and the effects of fluorine substitution and ring strain in molecular design.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke intermediates under cGMP or research-grade conditions.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 3,3-Difluoro-, Methyl Ester
CAS No.	1234616-13-7
Molecular Formula	C7H10F2O2
Molecular Weight	164.15 g/mol
Synonyms	Methyl 3,3-difluorocyclobutanecarboxylate; 3,3-Difluorocyclobutanecarboxylic Acid Methyl Ester; 3,3-Difluorocyclobutane-1-carboxylic acid methyl ester; Methyl 3,3-difluorocyclobutane-1-carboxylate; 1-Carbomethoxy-3,3-difluorocyclobutane; Difluorocyclobutanecarboxylic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Every batch of Cyclobutanecarboxylic Acid, 3,3-Difluoro-, Methyl Ester is produced and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including chromatographic purity analysis and identity confirmation, to ensure compliance with industry standards and customer specifications. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.