Description

Bicyclo[2.2.1]Hept-5-Ene-2-Acetic Acid, 2,5-Dioxo-1-Pyrrolidinyl Ester is a specialized, high-purity chemical intermediate featuring a reactive N-hydroxysuccinimide (NHS) ester group. This compound is critical for facilitating efficient and selective bioconjugation and crosslinking reactions in advanced chemical synthesis. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for developing novel therapeutics, diagnostic agents, and functional polymers.

Application

• Bioconjugation Reagent: Used for coupling peptides, proteins, and antibodies to other biomolecules, surfaces, or carriers for drug delivery and diagnostic applications.
• Polymer Functionalization: Serves as a key monomer or crosslinker for synthesizing and modifying polymers with specific reactive sites for advanced material science.
• Pharmaceutical Intermediate: Employed in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs requiring controlled release or targeted delivery mechanisms.
• Proteomics Research: Facilitates the labeling and modification of proteins for mass spectrometry analysis and other proteomic studies.
• Surface Immobilization: Enables the covalent attachment of bioactive molecules to sensor chips, nanoparticles, and other solid supports for biosensor development.
• Diagnostic Kit Manufacturing: A critical component in the production of enzyme-linked immunosorbent assay (ELISA) kits and other immunoassay reagents.

Basic Information

Product Name	Bicyclo[2.2.1]Hept-5-Ene-2-Acetic Acid, 2,5-Dioxo-1-Pyrrolidinyl Ester
CAS No.	1234203-45-2
Molecular Formula	C13H15NO4
Molecular Weight	249.26 g/mol
Synonyms	5-Norbornene-2-acetic acid N-hydroxysuccinimide ester; Norbornene NHS ester; Bicyclo[2.2.1]hept-5-ene-2-acetic acid N-succinimidyl ester; 2,5-Dioxopyrrolidin-1-yl bicyclo[2.2.1]hept-5-ene-2-acetate; NHS ester of norbornene acetic acid; Norbornene-acetic acid NHS ester; NB-NHS ester; 5-NBE-NHS
EINECS	Contact for details

Quality Control

Our Bicyclo[2.2.1]Hept-5-Ene-2-Acetic Acid, 2,5-Dioxo-1-Pyrrolidinyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.