Description

5-Nitro-n-(Piperidin-4-Yl)Pyridin-2-Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound serves as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for targeted therapies. It is essential for R&D chemists and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors developing next-generation drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially kinase inhibitors and other targeted small-molecule therapeutics.
• Chemical Research & Development: Used as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the multi-step manufacturing process of final drug substances requiring a specific nitro-amine-pyridine pharmacophore.
• Bioconjugation & Probe Development: Useful for creating chemical probes and bioconjugates for biochemical and diagnostic applications due to its reactive amine functionality.
• Academic Research: Serves as a standard or starting material in university and institutional labs for organic synthesis and pharmacological studies.

Basic Information

Item	Details
Product Name	5-Nitro-n-(Piperidin-4-Yl)Pyridin-2-Amine Hydrochloride
CAS No.	1233954-90-9
Molecular Formula	C10H15N4O2 • HCl
Molecular Weight	258.71 g/mol (Free base: 222.25 g/mol)
Synonyms	5-Nitro-N-(piperidin-4-yl)pyridin-2-amine hydrochloride; 2-Amino-5-nitro-N-(4-piperidinyl)pyridine hydrochloride; 4-[(5-Nitropyridin-2-yl)amino]piperidine hydrochloride; 5-Nitro-2-(4-piperidinylamino)pyridine hydrochloride; 1233954-90-9; 5-Nitro-N-(4-piperidinyl)-2-pyridinamine hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 5-Nitro-n-(Piperidin-4-Yl)Pyridin-2-Amine Hydrochloride is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the stringent requirements for pharmaceutical R&D and cGMP starting material applications. A detailed Certificate of Analysis (COA) including purity (HPLC), identity (IR, NMR), and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to brown crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.