Description

tert-Butyl 4-[(3-Aminopyridin-2-Ylamino)Methyl]Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex molecular architecture combining piperidine and aminopyridine motifs. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors, particularly in programs targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potential drug candidates, especially those with kinase inhibitory or receptor-modulating activity.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization stages to explore structure-activity relationships (SAR) and improve pharmacokinetic properties.
• Process Chemistry Development: Serves as a standard or starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Bioconjugation & Probe Synthesis: The reactive amine and protected carboxylate groups allow for further functionalization to create chemical probes for biological target identification and validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical industry.

Basic Information

Item	Details
Product Name	tert-Butyl 4-[(3-Aminopyridin-2-Ylamino)Methyl]Piperidine-1-Carboxylate
CAS No.	1233952-88-9
Molecular Formula	C16H26N4O2
Molecular Weight	306.41 g/mol
Synonyms	1-Boc-4-[(3-Amino-2-pyridinylamino)methyl]piperidine; 1-(tert-Butoxycarbonyl)-4-[(3-amino-2-pyridinylamino)methyl]piperidine; 4-[(3-Aminopyridin-2-ylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-({[3-aminopyridin-2-yl]amino}methyl)piperidine-1-carboxylate; 1233952-88-9; BOC-protected aminopyridinylpiperidine intermediate
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl 4-[(3-Aminopyridin-2-Ylamino)Methyl]Piperidine-1-Carboxylate is manufactured and tested under a strict quality management system. We ensure compliance with ICH guidelines for impurities and utilize advanced analytical techniques including HPLC, GC, and NMR for identity and purity verification. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.