Description

(S)-tert-Butyl3-(2-Fluoro-6-Nitrophenoxy)Pyrrolidine-1-Carboxylate is a high-purity chiral building block and advanced pharmaceutical intermediate. Its value lies in its defined stereochemistry and functionalized structure, which are critical for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs). This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries, particularly for projects involving fluorinated and nitrated bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of enantiomerically pure herbicides and pesticides, where the (S)-configuration can be crucial for biological activity.
• Asymmetric Catalysis Research: Serves as a valuable ligand precursor or a model substrate for developing new catalytic methodologies.
• Chemical Biology Probes: Employed in the creation of fluorinated molecular probes for studying enzyme mechanisms and binding interactions.
• Process Chemistry & Scale-Up: Provides a reliable, high-quality starting material for optimizing and scaling synthetic routes from lab to pilot plant.

Basic Information

Item	Details
Product Name	(S)-tert-Butyl3-(2-Fluoro-6-Nitrophenoxy)Pyrrolidine-1-Carboxylate
CAS No.	1233860-33-7
Molecular Formula	C15H19FN2O5
Molecular Weight	326.32 g/mol
Synonyms	(S)-1-Boc-3-(2-Fluoro-6-nitrophenoxy)pyrrolidine; (S)-tert-Butyl 3-(2-fluoro-6-nitrophenoxy)pyrrolidine-1-carboxylate; 1-Pyrrolidinecarboxylic acid, 3-(2-fluoro-6-nitrophenoxy)-, 1,1-dimethylethyl ester, (3S)-; (S)-3-(2-Fluoro-6-nitrophenoxy)-1-(tert-butoxycarbonyl)pyrrolidine; (S)-N-Boc-3-(2-fluoro-6-nitrophenoxy)pyrrolidine; (S)-1-(tert-Butoxycarbonyl)-3-(2-fluoro-6-nitrophenoxy)pyrrolidine; Boc-(S)-3-(2-Fluoro-6-nitrophenoxy)pyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl3-(2-Fluoro-6-Nitrophenoxy)Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high enantiomeric excess (ee) and chemical purity suitable for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.