Description

(1R,3R,4S)-4-(tert-Butyldiphenylsilyloxy)-2-Methylene-3-(Trityloxymethyl)Cyclopentanol is a high-purity, advanced pharmaceutical intermediate featuring multiple protecting groups. This compound is critical for enabling complex, stereoselective synthetic routes in modern organic chemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers for the development and production of novel active pharmaceutical ingredients (APIs), particularly in the nucleoside and antiviral therapeutic areas.

Application

• Key Intermediate in Nucleoside Analog Synthesis: Serves as a crucial building block for the preparation of modified nucleosides used in antiviral and anticancer drug candidates.
• Pharmaceutical Research & Development (R&D): Employed in medicinal chemistry programs for the exploration of new chemical entities and prodrug strategies.
• Process Chemistry & Scale-Up: Used in the optimization and pilot-scale manufacturing of complex target molecules requiring specific stereochemistry.
• Academic & Industrial Organic Synthesis: A valuable reagent for methodologies development, particularly in carbohydrate and cyclopentanol chemistry.
• Protecting Group Strategy: The tert-butyldiphenylsilyl (TBDPS) and trityl (Tr) groups allow for selective deprotection in multi-step synthesis.

Basic Information

Item	Detail
Product Name	(1R,3R,4S)-4-(tert-Butyldiphenylsilyloxy)-2-Methylene-3-(Trityloxymethyl)Cyclopentanol
CAS No.	1233193-58-2
Molecular Formula	C46H48O3Si
Molecular Weight	677.0 g/mol
Synonyms	4-[(1,1-Dimethylethyl)diphenylsilyl]oxy-2-methylene-3-[(triphenylmethoxy)methyl]-1-cyclopentanol (1R,3R,4S); (1R,3R,4S)-4-[(tert-Butyldiphenylsilyl)oxy]-2-methylene-3-[(trityloxy)methyl]cyclopentanol; TBDPS/Tr-Protected Cyclopentanol Intermediate; 2-Methylene-3-trityloxymethyl-4-TBDPSO-cyclopentanol; CAS 1233193-58-2; Advanced Nucleoside Intermediate; Stereoisomerically Pure Cyclopentanol Derivative.
EINECS	Contact for details

Quality Control

Every batch of this high-value intermediate is produced under strict quality management systems. We guarantee high chemical and chiral purity through comprehensive analytical techniques including HPLC, NMR, and chiral analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and conformity to customer specifications. Our manufacturing adheres to cGMP standards where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.