Description

8-Oxo-5-Aza-Spiro[2.5]Octane-5-Carboxylic Acid Benzyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and aza-oxo structure. This compound is of significant value for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic pathways. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, where consistent quality and reliable supply are critical.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel drug candidates, especially in medicinal chemistry research.
• Protease Inhibitor Development: Used in the research and production of enzyme inhibitors due to its reactive ester and constrained spirocyclic framework.
• Peptidomimetic Synthesis: Acts as a scaffold for creating peptide-like molecules with enhanced metabolic stability and bioavailability.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological targets and pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API synthesis projects.
• Academic & Industrial R&D: Employed in exploratory chemistry within academic laboratories and industrial R&D departments for new molecule discovery.

Basic Information

Product Name	8-Oxo-5-Aza-Spiro[2.5]Octane-5-Carboxylic Acid Benzyl Ester
CAS No.	1232542-21-0
Molecular Formula	C15H17NO3
Molecular Weight	259.30 g/mol
Synonyms	5-Aza-8-oxospiro[2.5]octane-5-carboxylic acid phenylmethyl ester; Benzyl 8-oxo-5-azaspiro[2.5]octane-5-carboxylate; 5-Carbobenzyloxy-8-oxo-5-azaspiro[2.5]octane; 5-Azaspirononane-8-one-5-carboxylic acid benzyl ester; 5-(Benzyloxycarbonyl)-8-oxo-5-azaspiro[2.5]octane; Spirocyclic Proline Derivative Benzyl Ester
EINECS	Contact for details

Quality Control

Our 8-Oxo-5-Aza-Spiro[2.5]Octane-5-Carboxylic Acid Benzyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.