Description

Baf-312 (Siponimod) is a potent and selective sphingosine-1-phosphate (S1P) receptor modulator, a key active pharmaceutical ingredient (API) in the treatment of multiple sclerosis. Its primary value lies in its targeted mechanism of action, which helps to reduce the frequency of relapses and delay disease progression. This high-purity compound is essential for pharmaceutical manufacturers and research institutions engaged in the development and production of advanced neurological therapies and related clinical studies.

Application

• Active Pharmaceutical Ingredient (API): Primary use in the formulation of oral dosage forms for the treatment of relapsing forms of multiple sclerosis (MS), including secondary progressive MS (SPMS).
• Pharmaceutical Research & Development: Critical reference standard and building block in preclinical and clinical studies exploring S1P receptor modulation.
• Neurological Drug Development: Serves as a key compound for developing next-generation therapies targeting autoimmune and inflammatory disorders of the central nervous system.
• Bioavailability & Formulation Studies: Used in research to optimize drug delivery systems and enhance the pharmacokinetic profile of S1P modulators.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the commercial-scale synthesis of finished drug products.
• Academic & Clinical Research: Utilized in university and hospital labs to investigate the broader therapeutic potential of S1P pathway modulation in other autoimmune conditions.

Basic Information

Item	Detail
Product Name	Baf-312 (Siponimod)
CAS No.	1230487-00-9
Molecular Formula	C29H35F3N2O3
Molecular Weight	516.60 g/mol
Synonyms	Siponimod; BAF-312; BAF312; 1-{4-[(1E)-1-({[4-cyclohexyl-3-(trifluoromethyl)phenyl]amino}carbonyl)ethenyl]-2-ethylbenzyl}azetidine-3-carboxylic acid; (1E)-1-{4-[1-(4-cyclohexyl-3-trifluoromethyl-phenylcarbamoyl)-vinyl]-2-ethyl-benzyl}-azetidine-3-carboxylic acid; Mayzent (brand name)
EINECS	Contact for details

Quality Control

Our Baf-312 (Siponimod) is manufactured under strict quality systems to ensure it meets the stringent requirements for pharmaceutical actives. Every batch is supported by a comprehensive Certificate of Analysis (COA) confirming identity, purity, and impurity profiles. We adhere to ICH guidelines and can supply material suitable for use under current Good Manufacturing Practice (GMP) standards for advanced clinical and commercial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single unknown impurity ≤ 0.10%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.