Description

3-(1-(tert-Butyldimethylsilyl)-1H-Indol-5-Yl)Benzoic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected indole moiety. This compound is critical for enabling complex synthetic routes in medicinal chemistry, particularly for the development of novel therapeutic agents. It is primarily required by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug molecules, particularly those targeting neurological and oncological pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and pharmacokinetic profiles.
• Process Chemistry & Scale-Up: Serves as a critical intermediate in the development and optimization of scalable, cost-effective manufacturing processes for APIs.
• Bioconjugation & Probe Development: The carboxylic acid functional group allows for conjugation to biomolecules, peptides, or fluorescent tags for use in biochemical assays and diagnostic tools.
• Academic & Institutional Research: Employed in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis organizations (CSOs) and CDMOs producing specialized compounds for client projects.

Basic Information

Product Name	3-(1-(tert-Butyldimethylsilyl)-1H-Indol-5-Yl)Benzoic Acid
CAS No.	1228957-08-1
Molecular Formula	C21H25NO2Si
Molecular Weight	351.52 g/mol
Synonyms	3-[1-[(1,1-Dimethylethyl)dimethylsilyl]-1H-indol-5-yl]benzoic acid; 3-(1-(Tert-butyldimethylsilyl)-1H-indol-5-yl)benzoic acid; 5-(3-Carboxyphenyl)-1-(tert-butyldimethylsilyl)indole; 1-(tert-Butyldimethylsilyl)-5-(3-carboxyphenyl)indole; TBDMS-Indole-5-Benzoic Acid; 1228957-08-1; Benzoic acid, 3-[1-[(1,1-dimethylethyl)dimethylsilyl]-1H-indol-5-yl]-
EINECS	Contact for details

Quality Control

Our 3-(1-(tert-Butyldimethylsilyl)-1H-Indol-5-Yl)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is sensitive to fluoride and strong alkali; ensure it is stored separately from such materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.