Description

2-Bromo-5-Formylbenzonitrile is a versatile and high-value aromatic building block featuring both bromo and formyl functional groups on a benzonitrile core. This unique trifunctional structure makes it a critical intermediate for the synthesis of complex molecules, particularly in pharmaceutical and advanced material research. It is essential for chemists and R&D teams engaged in developing active pharmaceutical ingredients (APIs), agrochemicals, and functional organic materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially in constructing heterocyclic compounds and kinase inhibitors.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and pesticides, leveraging its reactive sites for structural diversification.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and organic synthesis.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and other functional polymers due to its electron-withdrawing nitrile group and formyl handle.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to build complex biaryl systems.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems.

Basic Information

Product Name	2-Bromo-5-Formylbenzonitrile
CAS No.	1228829-43-3
Molecular Formula	C8H4BrNO
Molecular Weight	210.03 g/mol
Synonyms	5-Formyl-2-bromobenzonitrile; 2-Bromo-5-cyanobenzaldehyde; 5-Bromo-2-formylbenzonitrile; Benzonitrile, 2-bromo-5-formyl-; 2-Bromo-5-formylbenzonitrile; 2-Bromo-5-aldehydrobenzonitrile; 5-Cyano-2-bromobenzaldehyde
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Formylbenzonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere for prolonged procedures to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.