Description

6-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoro-3-Iodopyridine is a sophisticated, multi-functional chemical intermediate designed for advanced pharmaceutical synthesis. Its molecular architecture, featuring a protected hydroxyl group, a fluorinated pyridine core, and an iodine handle, makes it a versatile building block for constructing complex bioactive molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its modifiable fluorine and iodine substituents.
• Agrochemical Synthesis: Serves as a building block for developing new crop protection agents and herbicides.
• Cross-Coupling Reactions: The aryl iodide moiety is highly reactive in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) for carbon-carbon bond formation.
• Fluorinated Compound Libraries: Integral for creating libraries of fluorinated compounds to enhance metabolic stability and membrane permeability in drug candidates.
• Protecting Group Chemistry: The tert-butyldimethylsilyl (TBDMS) protecting group allows for selective deprotection in multi-step synthetic sequences.

Basic Information

Product Name	6-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoro-3-Iodopyridine
CAS No.	1228666-57-6
Molecular Formula	C16H26FIN2OSi
Molecular Weight	452.39 g/mol
Synonyms	2-Fluoro-3-iodo-6-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-pyrrolidinyl]pyridine; 2-Fluoro-3-iodo-6-(3-(((tert-butyldimethylsilyl)oxy)methyl)pyrrolidin-1-yl)pyridine; 6-(3-((Tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoro-3-Iodopyridine; 1228666-57-6; TBDMS-protected fluoroidopyridine intermediate; 1-(2-Fluoro-3-iodopyridin-6-yl)-3-((tert-butyldimethylsilyloxy)methyl)pyrrolidine
EINECS	Contact for details

Quality Control

Every batch of our 6-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoro-3-Iodopyridine is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive pharmaceutical R&D. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.