Description

1-(6-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoropyridin-3-Yl)Ethanone is a high-purity, advanced pharmaceutical intermediate featuring a unique pyrrolidine-pyridine scaffold with a fluorinated aromatic ring and a tert-butyldimethylsilyl (TBDMS) protecting group. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel drug candidates with enhanced metabolic stability and bioavailability. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers specializing in the production of complex, small-molecule active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization due to its fluoropyridine and protected alcohol functionalities.
• Process Chemistry Development: Serves as a critical intermediate in scaling up synthetic routes for preclinical and clinical trial material production.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of proprietary compounds for clients.
• Protecting Group Chemistry: The TBDMS group allows for selective reactions elsewhere on the molecule, which is essential in multi-step synthetic sequences.
• Fluorinated Compound Library Synthesis: Used to create libraries of fluorinated heterocycles for high-throughput screening in drug discovery.

Basic Information

Product Name	1-(6-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoropyridin-3-Yl)Ethanone
CAS No.	1228666-50-9
Molecular Formula	C18H29FN2O2Si
Molecular Weight	352.52 g/mol
Synonyms	1-[6-[3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]-1-pyrrolidinyl]-2-fluoro-3-pyridinyl]ethanone; 1-(6-(3-((Tert-Butyldimethylsilyloxy)Methyl)-1-Pyrrolidinyl)-2-fluoro-3-pyridinyl)ethanone; 2-Fluoro-3-acetyl-6-(3-((tert-butyldimethylsilyloxy)methyl)pyrrolidin-1-yl)pyridine; TBDMS-protected fluoropyridinyl pyrrolidine ketone; CAS 1228666-50-9
EINECS	Contact for details

Quality Control

Our 1-(6-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoropyridin-3-Yl)Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is sensitive to strong alkali and fluoride sources; ensure it is stored separately from such materials. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single unknown impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.