Description

5-Bromo-2-Pivalamidopyridin-4-Yl Pivalate is a high-purity, advanced pharmaceutical intermediate characterized by its specific brominated pyridine core protected with pivaloyl groups. This compound matters for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in kinase inhibitor research and development. Pharmaceutical, agrochemical, and advanced material research laboratories require this intermediate for its precise molecular architecture, which enables the construction of targeted bioactive molecules with high efficacy.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in developing novel crop protection agents and herbicides due to its heterocyclic structure.
• Chemical Biology Probes: Serves as a precursor for labeled compounds and probes used in mechanistic studies and target identification.
• Material Science: Potential building block for organic electronic materials and ligands in catalytic systems.
• Contract Research & Development (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client projects.

Basic Information

Product Name	5-Bromo-2-Pivalamidopyridin-4-Yl Pivalate
CAS No.	1228666-33-8
Molecular Formula	C16H21BrN2O3
Molecular Weight	369.26 g/mol
Synonyms	5-Bromo-2-pivalamidopyridin-4-yl pivalate; 4-Pyridinol, 5-bromo-2-[[(2,2-dimethyl-1-oxopropoxy)amino]-, 2,2-dimethylpropanoate (ester); 2,2-Dimethyl-N-(5-bromo-4-((2,2-dimethylpropanoyl)oxy)pyridin-2-yl)propanamide; 5-Bromo-2-(pivalamido)pyridin-4-yl pivalate; Pivalic acid, 5-bromo-2-pivalamido-4-pyridinyl ester; 1228666-33-8
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Pivalamidopyridin-4-Yl Pivalate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.