Description

5-Bromo-2-Ethyl-1H-Pyrrolo[2,3-B]Pyridine is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused heterocyclic structure. This compound is of significant commercial value as a critical building block in the synthesis of novel, biologically active molecules, particularly in drug discovery pipelines. It is primarily sought after by research institutions and pharmaceutical companies engaged in developing small-molecule therapeutics, especially kinase inhibitors and other targeted oncology treatments.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, particularly those targeting protein kinases.
• Drug Discovery & Medicinal Chemistry: Serves as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Oncology Research: Used in the development of novel kinase inhibitors for cancer treatment, leveraging its pyrrolopyridine core which is a privileged structure in many approved drugs.
• Chemical Biology: Employed as a molecular probe or a tagged ligand for studying enzyme mechanisms and target engagement in cellular assays.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical clients with custom synthesis and process development.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Item	Detail
Product Name	5-Bromo-2-Ethyl-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1228666-29-2
Molecular Formula	C9H9BrN2
Molecular Weight	225.09 g/mol
Synonyms	5-Bromo-2-ethyl-1H-pyrrolo[2,3-b]pyridine; 2-Ethyl-5-bromo-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-2-ethyl-7-azaindole; 5-Bromo-2-ethyl-1H-7-azaindole; 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-2-ethyl-; 1228666-29-2; 5-Br-2-Et-7-azaindole
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Ethyl-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.