Description

6-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoronicotinic Acid is a high-purity, advanced pharmaceutical intermediate featuring a complex molecular architecture designed for targeted synthesis. This compound is critical for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated chemical scaffolds. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the synthesis of complex drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug molecules, particularly those targeting neurological and oncological pathways.
• Active Pharmaceutical Ingredient (API) Development: Serves as a crucial precursor in the research and development of new APIs, leveraging its fluoronicotinic acid and protected pyrrolidine motifs.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and the exploration of new chemical entities (NCEs) in drug discovery programs.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and pilot-scale production for clinical trial material (CTM) manufacturing.
• Proteolysis Targeting Chimera (PROTAC) Synthesis: A potential component in the construction of heterobifunctional molecules for targeted protein degradation therapies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical manufacturers for bespoke synthesis projects under cGMP or research-grade conditions.

Basic Information

Item	Details
Product Name	6-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoronicotinic Acid
CAS No.	1228666-21-4
Molecular Formula	C20H31FN2O3Si
Molecular Weight	394.56 g/mol
Synonyms	2-Fluoro-6-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-pyrrolidinyl]-3-pyridinecarboxylic acid; 6-(3-((Tert-butyldimethylsilyloxy)methyl)pyrrolidin-1-yl)-2-fluoronicotinic acid; 2-Fluoro-6-(3-(((tert-butyldimethylsilyl)oxy)methyl)pyrrolidin-1-yl)nicotinic acid; TBDMS-protected fluoronicotinic acid-pyrrolidine intermediate; CAS 1228666-21-4
EINECS	Contact for details

Quality Control

Our production of 6-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoronicotinic Acid adheres to stringent quality protocols suitable for pharmaceutical R&D and pre-clinical applications. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is sensitive to strong acids and organic solvents; ensure storage areas are free from such incompatible materials. For long-term storage, consider inert atmosphere conditions to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.