Description

5-Fluoro-1-(Triisopropylsilyl)-4-((Trimethylsilyl) Ethynyl)-1H-Pyrrolo[2,3-B]Pyridine is a high-value, multi-functionalized pyrrolopyridine derivative designed for advanced synthetic chemistry. This compound serves as a critical key intermediate and building block in the development of complex molecules, offering versatile reactivity for cross-coupling and functionalization reactions. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in kinase inhibitor research and other targeted therapies.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging its unique fluorinated pyrrolopyridine core.
• Material Science Research: Serves as a precursor for organic electronic materials and ligands for catalytic systems due to its silyl-protected ethynyl group.
• Cross-Coupling Reactions: The silyl-protected alkyne and halogenated structure make it an excellent substrate for Sonogashira, Suzuki, and other palladium-catalyzed couplings.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring complex, functionalized heterocycles.

Basic Information

Item	Details
Product Name	5-Fluoro-1-(Triisopropylsilyl)-4-((Trimethylsilyl) Ethynyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1228666-08-7
Molecular Formula	C23H37FNSi2
Molecular Weight	405.72 g/mol
Synonyms	4-((Trimethylsilyl)ethynyl)-5-fluoro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 5-fluoro-1-(triisopropylsilyl)-4-[(trimethylsilyl)ethynyl]-; 5-Fluoro-1-TIPS-4-TMS-ethynyl-1H-pyrrolo[2,3-b]pyridine; TIPS/TMS-protected Fluoropyrrolopyridine; Fluorinated Pyrrolopyridine Alkyne Derivative; CAS 1228666-08-7
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request. We adhere to a cGMP-compliant quality management system to support our clients in pharmaceutical and high-purity applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.