Description

2,3-Dihydro-1H-Pyrido[3,4-B][1,4]Oxazine-8-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its fused heterocyclic structure. This compound is of significant commercial importance as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of complex drug candidates, especially those targeting the central nervous system (CNS) and oncology.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Employed in the multi-step manufacturing process of final Active Pharmaceutical Ingredients (APIs) requiring the pyridooxazine core.
• Contract Manufacturing: Supplied to CDMOs for custom synthesis projects and scale-up activities from laboratory to pilot plant scale.
• Biochemical Research: May be utilized as a tool compound or ligand in biochemical assays and proteomics research.

Basic Information

Item	Detail
Product Name	2,3-Dihydro-1H-Pyrido[3,4-B][1,4]Oxazine-8-Carboxylic Acid
CAS No.	1228665-92-6
Molecular Formula	C9H8N2O3
Molecular Weight	192.17 g/mol
Synonyms	8-Carboxy-2,3-dihydro-1H-pyrido[3,4-b][1,4]oxazine; 1H-Pyrido[3,4-b][1,4]oxazine-8-carboxylic acid, 2,3-dihydro-; 2,3-Dihydro-1H-pyrido[3,4-b][1,4]oxazine-8-carboxylic acid; Pyrido[3,4-b][1,4]oxazine-8-carboxylic acid, 2,3-dihydro-1H-; 1228665-92-6; 8-Carboxy-2,3-dihydro-1H-pyrido[3,4-b]oxazine
EINECS	Contact for details

Quality Control

Our 2,3-Dihydro-1H-Pyrido[3,4-B][1,4]Oxazine-8-Carboxylic Acid is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing all specifications and test results to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.