Description

tert-Butyl 3-(2-Methoxy-5-Methylpyridin-3-Yl)-Pyrrolidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic structure. This compound is of critical importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of complex drug molecules, especially those targeting the central nervous system.
• API Synthesis: Used in the research and development of new Active Pharmaceutical Ingredients (APIs) where its specific pyrrolidine-pyridine scaffold is required for biological activity.
• Medicinal Chemistry Research: A valuable scaffold for constructing compound libraries in drug discovery programs for structure-activity relationship (SAR) studies.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and commercial drug substances under GMP guidelines.

Basic Information

Product Name	tert-Butyl 3-(2-Methoxy-5-Methylpyridin-3-Yl)-Pyrrolidine-1-Carboxylate
CAS No.	1228665-86-8
Molecular Formula	C16H24N2O3
Molecular Weight	292.38 g/mol
Synonyms	1-Boc-3-(2-methoxy-5-methyl-3-pyridyl)pyrrolidine; 1-(tert-Butoxycarbonyl)-3-(2-methoxy-5-methyl-3-pyridinyl)pyrrolidine; tert-Butyl 3-(2-methoxy-5-methylpyridin-3-yl)pyrrolidine-1-carboxylate; 3-(2-Methoxy-5-methylpyridin-3-yl)pyrrolidine-1-carboxylic acid tert-butyl ester; Pyrrolidine, 3-(2-methoxy-5-methyl-3-pyridinyl)-, 1-(1,1-dimethylethyl) ester; 1228665-86-8; Boc-3-(2-methoxy-5-methyl-3-pyridyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(2-Methoxy-5-Methylpyridin-3-Yl)-Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with internal specifications and customer quality agreements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.