Description

Benzyl (3S,4R)-4-Amino-3-Fluoropiperidine-1-Carboxylate CAS NO 1228631-13-7 is a high-purity, chiral fluorinated piperidine derivative serving as a critical building block in advanced organic synthesis. This compound is essential for pharmaceutical research and development, particularly in the creation of novel active pharmaceutical ingredients (APIs) where its specific stereochemistry and fluorine atom introduce desirable metabolic stability and binding properties. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Process Chemistry Development: Serves as a starting material or advanced intermediate in the scalable synthesis of complex molecules under Good Manufacturing Practice (GMP) conditions.
• Agrochemical Synthesis: Employed in the development of novel pesticides and herbicides where the fluorinated piperidine scaffold can enhance biological activity.
• Ligand and Catalyst Preparation: Useful for constructing chiral ligands for asymmetric catalysis or as a component in organocatalysts.

Basic Information

Product Name	Benzyl (3S,4R)-4-Amino-3-Fluoropiperidine-1-Carboxylate
CAS No.	1228631-13-7
Molecular Formula	C13H17FN2O2
Molecular Weight	252.29 g/mol
Synonyms	1-CBz-3-Fluoro-4-Aminopiperidine (3S,4R)-Isomer; (3S,4R)-1-(Benzyloxycarbonyl)-3-fluoro-4-aminopiperidine; Benzyl N-[(3S,4R)-3-fluoro-4-aminopiperidin-1-yl]formate; 1-Benzyloxycarbonyl-3-fluoro-4-aminopiperidine; (3S,4R)-4-Amino-3-fluoropiperidine-1-carboxylic acid benzyl ester; 3-Fluoro-4-aminopiperidine-1-carboxylate benzyl ester; 1228631-13-7; Cbz-3-F-4-NH2-Piperidine
EINECS	Contact for details

Quality Control

Our Benzyl (3S,4R)-4-Amino-3-Fluoropiperidine-1-Carboxylate is manufactured under strict quality control protocols to ensure high chemical and chiral purity, meeting the stringent requirements of research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We adhere to relevant industry standards and can support development towards cGMP-grade material upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.