Description

(1R)-2,2,2-Trifluoro-1-(2-Pyridyl)Ethylamine CAS NO 1228565-87-4 is a high-purity chiral amine building block featuring a trifluoromethyl group and a pyridine moiety, offering unique electronic and steric properties for advanced synthesis. This compound is critical for medicinal chemistry research, enabling the development of novel pharmaceuticals with enhanced metabolic stability and binding affinity. It is primarily needed by pharmaceutical R&D departments, agrochemical innovators, and specialty chemical manufacturers for creating active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral drugs.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides where the trifluoromethyl group improves lipophilicity and biological activity.
• Ligand Precursor: Serves as a starting material for synthesizing chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Fluorine-Containing Compound Research: Essential for studying structure-activity relationships (SAR) in drug discovery due to its distinct fluorine atom properties.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and dyes.
• Academic & Industrial R&D: A valuable tool for chemists in universities and corporate labs exploring new synthetic methodologies and novel chemical entities.

Basic Information

Product Name	(1R)-2,2,2-Trifluoro-1-(2-Pyridyl)Ethylamine
CAS No.	1228565-87-4
Molecular Formula	C7H7F3N2
Molecular Weight	176.14 g/mol
Synonyms	(R)-1-(Pyridin-2-yl)-2,2,2-trifluoroethanamine; (1R)-1-(2-Pyridinyl)-2,2,2-trifluoroethanamine; (R)-2,2,2-Trifluoro-1-(pyridin-2-yl)ethan-1-amine; (R)-α-(Trifluoromethyl)-2-pyridineethanamine; (R)-1-(2-Pyridyl)-2,2,2-trifluoroethylamine; (R)-TFMPEA; (R)-2-Pyridyltrifluoroethylamine; (R)-Enantiomer of 2,2,2-Trifluoro-1-(2-pyridyl)ethylamine
EINECS	Contact for details

Quality Control

Our (1R)-2,2,2-Trifluoro-1-(2-Pyridyl)Ethylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting research and pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.