Description

(2R)-2-[2-(Trifluoromethyl)Phenyl]Pyrrolidine is a high-value, chiral pyrrolidine derivative featuring a strategically positioned trifluoromethylphenyl group, making it a critical building block in modern synthetic chemistry. Its primary value lies in its role as a sophisticated chiral intermediate for constructing complex, biologically active molecules, particularly within the pharmaceutical sector. This compound is essential for research and development chemists and process scale-up teams working on new active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Research: Used in developing advanced pesticides and herbicides where the chiral center and fluorine atoms contribute to enhanced biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to create enantiomerically pure compounds.
• Material Science: Potential building block for specialty polymers and liquid crystals, leveraging the electronic properties of the trifluoromethyl group.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client projects.
• Academic & Institutional Research: Used in university and government labs for methodological studies in organic and medicinal chemistry.

Basic Information

Product Name	(2R)-2-[2-(Trifluoromethyl)Phenyl]Pyrrolidine
CAS No.	1228557-00-3
Molecular Formula	C11H12F3N
Molecular Weight	215.22 g/mol
Synonyms	(R)-2-(2-(Trifluoromethyl)phenyl)pyrrolidine; (2R)-2-[2-(Trifluoromethyl)phenyl]pyrrolidine; (R)-2-(α,α,α-Trifluoro-o-tolyl)pyrrolidine; (R)-2-(2-Trifluoromethylphenyl)pyrrolidine; (R)-2-(2-Trifluoromethylphenyl)-1-pyrroline (reduced form); Chiral Pyrrolidine Trifluoromethyl Derivative; 2-(2-Trifluoromethylphenyl)pyrrolidine, (R)-
EINECS	Contact for details

Quality Control

Our (2R)-2-[2-(Trifluoromethyl)Phenyl]Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis (HPLC/Chiral SFC), to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess. We support compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider storage under an inert atmosphere (e.g., nitrogen or argon) to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC/SFC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.