Description

1,2-Pyrrolidinedicarboxylic Acid, 3-Methyl-, 1-(9H-Fluoren-9-Ylmethyl) Ester, (2S,3S)- is a high-purity, stereochemically defined building block of significant value in advanced organic synthesis. This compound, with CAS number 1228307-80-9, is specifically engineered for applications requiring precise molecular architecture and chiral integrity. It is primarily utilized by research institutions and pharmaceutical development teams engaged in the synthesis of complex molecules, including novel active pharmaceutical ingredients (APIs) and specialized peptides.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Serves as a protected amino acid derivative for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• Asymmetric Synthesis: Utilized as a building block in catalytic and stoichiometric asymmetric reactions to construct stereogenic centers.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the creation of focused compound libraries for drug discovery.
• Chemical Biology Probes: Used in the synthesis of labeled or modified molecules for studying biological pathways and protein interactions.
• Academic & Industrial R&D: A valuable reagent for methodology development and the synthesis of novel organic compounds in research laboratories.

Basic Information

Item	Details
Product Name	1,2-Pyrrolidinedicarboxylic Acid, 3-Methyl-, 1-(9H-Fluoren-9-Ylmethyl) Ester, (2S,3S)-
CAS No.	1228307-80-9
Molecular Formula	C21H21NO4
Molecular Weight	351.40 g/mol
Synonyms	(2S,3S)-3-Methyl-1-((9H-fluoren-9-yl)methyl) pyrrolidine-1,2-dicarboxylate; Fmoc-(2S,3S)-3-methylproline; (2S,3S)-1-Fmoc-3-methylproline; (2S,3S)-3-Methyl-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine-2-carboxylic acid; (2S,3S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methylpyrrolidine-2-carboxylic acid; Fmoc-3-MePro-OH; Fmoc-(2S,3S)-β-MePro-OH
EINECS	Contact for details

Quality Control

Our production of this advanced building block adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity. Every lot is characterized using advanced analytical techniques, including HPLC, chiral analysis, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.