Description

(Racemic Trans)-1-tert-Butyl 3-Methyl 4-(2-Chloro-5-Methylpyridin-3-Yl)Pyrrolidine-1,3-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functionalized pyrrolidine-pyridine hybrid structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex, biologically active molecules with precise spatial orientation. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly within central nervous system (CNS) and antiviral research pipelines.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Process Chemistry Development: Employed in route scouting and scale-up synthesis for preclinical and clinical trial material.
• Custom Synthesis: A starting material for the preparation of more complex, target-specific molecular libraries.
• Academic Research: Utilized in universities and institutes for studying asymmetric synthesis and heterocyclic chemistry.

Basic Information

Product Name	(Racemic Trans)-1-tert-Butyl 3-Methyl 4-(2-Chloro-5-Methylpyridin-3-Yl)Pyrrolidine-1,3-Dicarboxylate
CAS No.	1228070-72-1
Molecular Formula	C17H23ClN2O4
Molecular Weight	354.83 g/mol
Synonyms	1-tert-Butyl 3-methyl 4-(2-chloro-5-methylpyridin-3-yl)pyrrolidine-1,3-dicarboxylate; 1-(tert-Butoxycarbonyl)-3-methyl 4-(2-chloro-5-methyl-3-pyridinyl)-3-pyrrolidinecarboxylate; 4-(2-Chloro-5-methylpyridin-3-yl)-1-N-Boc-3-methyl pyrrolidine-1,3-dicarboxylate; trans-1-Boc-3-methyl 4-(2-chloro-5-methyl-3-pyridinyl)pyrrolidine-1,3-dicarboxylate; (±)-trans-1-tert-Butyl 3-methyl 4-(2-chloro-5-methylpyridin-3-yl)pyrrolidine-1,3-dicarboxylate; CAS 1228070-72-1
EINECS	Contact for details

Quality Control

Our (Racemic Trans)-1-tert-Butyl 3-Methyl 4-(2-Chloro-5-Methylpyridin-3-Yl)Pyrrolidine-1,3-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and isomeric purity suitable for demanding research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (trans isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.