Description

{[2-Methyl-6-(Trifluoromethyl)Pyridin-3-Yl]Methylene}Malononitrile is a specialized organic building block featuring a pyridine core substituted with a trifluoromethyl group and a reactive methylene-malononitrile moiety. This compound matters for its role as a key intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its unique structure imparts valuable electronic and physicochemical properties. Industries such as pharmaceutical R&D, agrochemical manufacturing, and organic electronics require this high-purity chemical for developing novel compounds with enhanced performance characteristics.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders or requiring fluorinated motifs for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trifluoromethylpyridine unit is known to enhance biological activity and environmental persistence.
• Organic Electronic Materials: Acts as an electron-accepting building block in the design of organic semiconductors, non-fullerene acceptors for solar cells, and electrochromic materials due to its strong electron-withdrawing character.
• Ligand and Catalyst Development: Employed in the preparation of specialized nitrogen-containing ligands for transition metal catalysis, useful in cross-coupling and other synthetic transformations.
• Fluorescent Probe and Dye Chemistry: Utilized as a core component in synthesizing fluorophores and molecular sensors, leveraging the conjugated system for tunable optical properties.
• Academic and Industrial Research: A valuable reagent for method development and exploring new chemical spaces in medicinal and materials chemistry research programs.

Basic Information

Item	Details
Product Name	{[2-Methyl-6-(Trifluoromethyl)Pyridin-3-Yl]Methylene}Malononitrile
CAS No.	1227955-29-4
Molecular Formula	C12H6F3N3
Molecular Weight	249.19 g/mol
Synonyms	2-({[2-Methyl-6-(trifluoromethyl)pyridin-3-yl]methylene})propanedinitrile; (2-Methyl-6-trifluoromethyl-pyridin-3-ylmethylene)-malononitrile; 2-((2-Methyl-6-(trifluoromethyl)pyridin-3-yl)methylene)malononitrile; Propanedinitrile, 2-[[2-methyl-6-(trifluoromethyl)-3-pyridinyl]methylene]-; 3-Pyridinecarbonitrile, 5-(dicyanomethylene)-2-methyl-6-(trifluoromethyl)-; 1227955-29-4; (2-Methyl-6-trifluoromethyl-3-pyridinylmethylene)malononitrile
EINECS	Contact for details

Quality Control

Our {[2-Methyl-6-(Trifluoromethyl)Pyridin-3-Yl]Methylene}Malononitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are provided and available upon request. We support cGMP and ISO compliant production for advanced application needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.