Description

(1-(5-Nitropyridin-2-Yl)Piperidin-4-Yl)Methanol is a high-purity, advanced pharmaceutical intermediate characterized by its nitropyridine and piperidine-containing structure. This compound is of significant value for its role as a critical building block in the synthesis of novel, complex active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of targeted therapeutics, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of potential drug candidates, especially those targeting specific enzymes or receptors.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the creation of focused compound libraries for high-throughput screening.
• API Synthesis: Integral in constructing the core scaffold of complex molecules during process research and development (PR&D) and scale-up activities.
• Biochemical Research: May be utilized as a tool compound or ligand in biochemical assays to study protein-ligand interactions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP guidelines.

Basic Information

Product Name	(1-(5-Nitropyridin-2-Yl)Piperidin-4-Yl)Methanol
CAS No.	1227935-27-4
Molecular Formula	C11H15N3O3
Molecular Weight	237.26 g/mol
Synonyms	4-(Hydroxymethyl)-1-(5-nitropyridin-2-yl)piperidine; 1-(5-Nitro-2-pyridinyl)-4-piperidinemethanol; (1-(5-Nitropyridin-2-yl)piperidin-4-yl)methanol; 2-(4-(Hydroxymethyl)piperidin-1-yl)-5-nitropyridine; 5-Nitro-2-(4-piperidinylmethoxy)pyridine (tautomeric form); 5-Nitro-2-(4-(hydroxymethyl)piperidin-1-yl)pyridine
EINECS	Contact for details

Quality Control

Our (1-(5-Nitropyridin-2-Yl)Piperidin-4-Yl)Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support development needs with custom purity grades and can align with relevant pharmacopeial guidelines (e.g., ICH Q3A/B) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be light-sensitive and/or hygroscopic; prolonged exposure to light, moisture, or extreme temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.