Description

5-Bromo-2-(bromomethyl)-3-chloropyridine is a high-value halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its unique substitution pattern, which provides multiple reactive sites for selective functionalization, enabling the construction of complex molecular architectures. It is primarily needed by pharmaceutical R&D teams and agrochemical manufacturers for developing novel active ingredients, as well as by specialty chemical companies engaged in materials science and ligand synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating novel chelating ligands and organocatalysts in asymmetric synthesis.
• Material Science Research: Building block for synthesizing functionalized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) due to its bromine substituents.
• Chemical Biology Probes: Used to create tagged molecules and probes for studying biological pathways and protein interactions.

Basic Information

Product Name	5-Bromo-2-(bromomethyl)-3-chloropyridine
CAS No.	1227606-75-8
Molecular Formula	C6H4Br2ClN
Molecular Weight	285.36 g/mol
Synonyms	3-Chloro-5-bromo-2-(bromomethyl)pyridine; 2-(Bromomethyl)-5-bromo-3-chloropyridine; 5-Bromo-3-chloro-2-(bromomethyl)pyridine; 1227606-75-8; 3-Chloro-2-(bromomethyl)-5-bromopyridine; Pyridine, 5-bromo-2-(bromomethyl)-3-chloro-; 5-Bromo-2-bromomethyl-3-chloropyridine
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(bromomethyl)-3-chloropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.