Description

2-Bromo-4-(Chloromethyl)-3-Fluoropyridine is a high-purity, multi-functional halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its unique reactivity profile, enabling the precise introduction of bromo, chloromethyl, and fluoro substituents into complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Building block for developing new-generation herbicides, fungicides, and insecticides that require specific halogenated pyridine cores.
• Material Science Research: Used in the creation of novel ligands for catalysis and functional monomers for specialty polymers.
• Cross-Coupling Reactions: Serves as a versatile substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromine atom.
• Nucleophilic Substitution: The chloromethyl group provides a handle for further functionalization through reactions with various nucleophiles.
• Contract Research & Development (CRO/CMO): Supplied to research organizations for library synthesis and medicinal chemistry programs.

Basic Information

Product Name	2-Bromo-4-(Chloromethyl)-3-Fluoropyridine
CAS No.	1227606-56-5
Molecular Formula	C6H4BrClFN
Molecular Weight	224.46 g/mol
Synonyms	3-Fluoro-2-bromo-4-(chloromethyl)pyridine; 4-(Chloromethyl)-2-bromo-3-fluoropyridine; 2-Bromo-3-fluoro-4-(chloromethyl)pyridine; 2-Bromo-4-chloromethyl-3-fluoropyridine; Pyridine, 2-bromo-4-(chloromethyl)-3-fluoro-; (2-Bromo-3-fluoro-4-pyridinyl)methyl chloride
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-4-(Chloromethyl)-3-Fluoropyridine is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including HPLC, GC, and NMR analysis, to ensure compliance with exacting industry standards and customer-specific requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.