Description

2-(Bromomethyl)-4-Fluoropyridine is a versatile and highly reactive halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic combination of a reactive bromomethyl group and a fluorine substituent, enabling precise molecular modifications. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce fluorinated pyridine motifs into complex molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and kinase inhibitors.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides that leverage the biological activity of fluorinated heterocycles.
• Ligand and Catalyst Development: Used to create sophisticated pyridine-based ligands for transition metal catalysis and organocatalysts.
• Material Science Research: Monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Employed in the design of molecular probes and tags for studying biological systems and drug-target interactions.
• Cross-Coupling Reactions: Serves as an electrophilic coupling partner in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.

Basic Information

Product Name	2-(Bromomethyl)-4-Fluoropyridine
CAS No.	1227606-51-0
Molecular Formula	C6H5BrFN
Molecular Weight	190.01 g/mol
Synonyms	4-Fluoro-2-(bromomethyl)pyridine; 2-Bromomethyl-4-fluoropyridine; 4-Fluoro-2-pyridinemethanol, bromo derivative; (4-Fluoropyridin-2-yl)methyl bromide; 4-Fluoro-2-(bromomethyl)pyridine; 1227606-51-0; 4-Fluoro-2-bromomethylpyridine
EINECS	Contact for details

Quality Control

Every batch of 2-(Bromomethyl)-4-Fluoropyridine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. Our standard grade meets high-purity specifications suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.