Description

2-Chloro-3-Chloromethyl-5-Fluoro-Pyridine is a high-value halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its multi-functional structure, featuring reactive chloro and chloromethyl groups on a fluorinated pyridine ring, makes it an indispensable intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting central nervous system and anti-infective applications.
• Agrochemical Synthesis: Used in the manufacture of advanced pesticides and herbicides, where the fluorine atom and pyridine core enhance biological activity and environmental stability.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic electronic materials.
• Custom Chemical Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	2-Chloro-3-Chloromethyl-5-Fluoro-Pyridine
CAS No.	1227606-13-4
Molecular Formula	C7H4Cl2FN
Molecular Weight	180.02 g/mol
Synonyms	5-Fluoro-2-chloro-3-(chloromethyl)pyridine; 3-(Chloromethyl)-2-chloro-5-fluoropyridine; 2-Chloro-5-fluoro-3-pyridinylmethyl chloride; 2-Chloro-3-chloromethyl-5-fluoropyridine; 1227606-13-4; 5-Fluoro-2-chloro-3-chloromethylpyridine; Pyridine, 2-chloro-3-(chloromethyl)-5-fluoro-
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-3-Chloromethyl-5-Fluoro-Pyridine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency suitable for sensitive synthesis applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.