Description

2-Bromo-5-Chloronicotinaldehyde is a versatile halogenated nicotinaldehyde derivative, serving as a key synthetic intermediate in advanced organic chemistry. Its value lies in providing a reactive aldehyde group and halogen handles for selective cross-coupling and functionalization reactions. This compound is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for constructing complex heterocyclic scaffolds, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, especially kinase inhibitors and other nitrogen-containing heterocycles.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging its halogenated pyridine core.
• Material Science Research: Serves as a precursor for creating functionalized ligands, organic semiconductors, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The bromo and chloro substituents make it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions.
• Chemical Derivatization: The aldehyde group is readily available for condensation, reduction, or oxidation to introduce diverse functional groups.

Basic Information

Product Name	2-Bromo-5-Chloronicotinaldehyde
CAS No.	1227605-52-8
Molecular Formula	C6H3BrClNO
Molecular Weight	220.45 g/mol
Synonyms	5-Chloro-2-bromonicotinaldehyde; 2-Bromo-5-chloropyridine-3-carboxaldehyde; 3-Formyl-2-bromo-5-chloropyridine; 2-Bromo-5-chloro-3-pyridinecarboxaldehyde; 5-Chloro-2-bromo-3-pyridinecarboxaldehyde; 2-Bromo-5-chloro-3-formylpyridine; 2-Bromo-5-chloronicotinaldehyde; Nicotinaldehyde, 2-bromo-5-chloro-
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Chloronicotinaldehyde is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.