Description

2-Chloro-3-(trifluoromethyl)-4-iodopyridine is a high-value, multi-functional halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethyl and halogen groups.
• Ligand and Catalyst Development: Serves as a sophisticated scaffold for creating novel ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Building block for organic electronic materials, such as non-linear optical (NLO) materials and charge-transport layers.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira) to introduce the pyridine core into complex architectures.
• Fluorine Chemistry: The presence of the CF3 group makes it valuable for studying structure-activity relationships (SAR) and metabolic stability in drug discovery.

Basic Information

Product Name	2-Chloro-3-(trifluoromethyl)-4-iodopyridine
CAS No.	1227603-55-5
Molecular Formula	C7H2ClF3IN
Molecular Weight	336.45 g/mol
Synonyms	4-Iodo-2-chloro-3-(trifluoromethyl)pyridine; 2-Chloro-4-iodo-3-(trifluoromethyl)pyridine; 3-(Trifluoromethyl)-2-chloro-4-iodopyridine; Pyridine, 2-chloro-3-(trifluoromethyl)-4-iodo-; 1227603-55-5
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-3-(trifluoromethyl)-4-iodopyridine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (typically by HPLC), identity confirmation (by IR and/or NMR), and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.