Description

2-Amino-3-Iodo-6-(Trifluoromethyl)Pyridine is a high-value, multi-functional halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring amino, iodo, and trifluoromethyl substituents, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyridine core and halogen atoms.
• Ligand Synthesis: Serves as a starting material for creating specialized ligands in catalysis and coordination chemistry.
• Material Science: Building block for organic electronic materials, such as OLEDs and semiconductors, where the trifluoromethyl group can tune electronic properties.
• Cross-Coupling Reactions: The iodine atom provides an excellent handle for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Fluorine Chemistry: The trifluoromethyl group makes it a valuable scaffold for introducing fluorine into target molecules to enhance metabolic stability and lipophilicity.

Basic Information

Product Name	2-Amino-3-Iodo-6-(Trifluoromethyl)Pyridine
CAS No.	1227602-97-2
Molecular Formula	C6H4F3IN2
Molecular Weight	287.01 g/mol
Synonyms	2-Amino-3-iodo-6-(trifluoromethyl)pyridine; 3-Iodo-6-(trifluoromethyl)pyridin-2-amine; 6-(Trifluoromethyl)-3-iodopyridin-2-amine; 2-Pyridinamine, 3-iodo-6-(trifluoromethyl)-; AI3-48839; ZINC000103249756; BCP31983; SCHEMBL21842219
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-3-Iodo-6-(Trifluoromethyl)Pyridine is manufactured and analyzed under strict quality management protocols to ensure consistency and purity for research and development applications. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing all specifications is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.