Description

4-Bromo-5-(Trifluoromethyl)Pyridin-2-Amine CAS NO 1227599-92-9 is a high-value, multi-functional pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromo and trifluoromethyl substituents, makes it an essential intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Development: Used in research to create novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to form complex biaryl and heteroaryl systems.
• Fluorine Chemistry: A valuable scaffold for introducing fluorine atoms into target molecules, a common strategy to improve metabolic stability and membrane permeability in drug design.

Basic Information

Product Name	4-Bromo-5-(Trifluoromethyl)Pyridin-2-Amine
CAS No.	1227599-92-9
Molecular Formula	C6H4BrF3N2
Molecular Weight	241.01 g/mol
Synonyms	2-Amino-4-bromo-5-(trifluoromethyl)pyridine; 4-Bromo-5-(trifluoromethyl)-2-pyridinamine; 4-Bromo-5-trifluoromethylpyridin-2-ylamine; 2-Pyridinamine, 4-bromo-5-(trifluoromethyl)-; 4-Bromo-5-(trifluoromethyl)-2-aminopyridine; 1227599-92-9
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-5-(Trifluoromethyl)Pyridin-2-Amine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and scale-up activities. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.