Description

3-Bromo-2-Fluoro-4-(Trifluoromethyl)Pyridine is a high-value, multi-halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and a trifluoromethyl group on the pyridine ring, makes it an indispensable intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for synthesizing functionalized ligands, organic electronic materials, and liquid crystals.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Fluorinated Compound Libraries: A valuable reagent for medicinal chemistry teams building diverse compound libraries to explore structure-activity relationships (SAR).

Basic Information

Product Name	3-Bromo-2-Fluoro-4-(Trifluoromethyl)Pyridine
CAS No.	1227599-89-4
Molecular Formula	C6H2BrF4N
Molecular Weight	243.99 g/mol
Synonyms	3-Bromo-2-fluoro-4-(trifluoromethyl)pyridine; 2-Fluoro-3-bromo-4-(trifluoromethyl)pyridine; 4-(Trifluoromethyl)-3-bromo-2-fluoropyridine; Pyridine, 3-bromo-2-fluoro-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Fluoro-4-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.