Description

4-Chloro-2-Fluoro-3-Methoxypyridine is a high-purity, multi-functional halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its value lies in its unique substitution pattern, which provides distinct reactivity for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for research chemists and process development scientists in fine chemical, pharmaceutical, and agrochemical industries who require reliable, high-quality intermediates for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the halogen and methoxy groups contribute to biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials due to its aromatic pyridine core and modifiable substituents.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in contract research and manufacturing organizations (CROs/CMOs).

Basic Information

Product Name	4-Chloro-2-Fluoro-3-Methoxypyridine
CAS No.	1227598-28-8
Molecular Formula	C6H5ClFNO
Molecular Weight	161.56 g/mol
Synonyms	3-Methoxy-4-chloro-2-fluoropyridine; 2-Fluoro-3-methoxy-4-chloropyridine; 4-Chloro-2-fluoro-3-methoxypyridine; 2-Fluoro-4-chloro-3-methoxypyridine; Pyridine, 4-chloro-2-fluoro-3-methoxy-; 1227598-28-8
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluoro-3-Methoxypyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring a reliable supply for demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Typical: 98.5% - 99.5%)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.